I stopped with cyclobenzaprine after a week and half. I was taking cyclobenzapr and percocets for a back engery and became very. Any weight loss with Merina. Does cyclobenzaprine cause weight loss. PicoTrace is a spin-off company, founded by members of the Faculty of Geosciences of the University of G Find patient medical information for Flexeril oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Can Cyclobenzaprine cause Weight Gain? Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. Cyclobenzaprine is a medication used to manage pain from muscle injuries. Anyhow, Wellbutrin,Tramadol & Savella have all been known to cause weight loss. ![]() FDA prescribing information, side effects and uses. Cyclobenzaprine hydrochloride is a white, crystalline tricyclic amine salt. It has a melting point of 2. It is freely soluble in water and alcohol, sparingly soluble in isopropanol, and insoluble in hydrocarbon solvents. If aqueous solutions are made alkaline, the free base separates. Cyclobenzaprine HCl is designated chemically as 3- (5. H- dibenzo. 3. 11. Cyclobenzaprine hydrochloride tablets, USP are available for oral administration as 5 mg, 7. Cyclobenzaprine hydrochloride 5 mg, 7. Cyclobenzaprine - Clinical Pharmacology. Cyclobenzaprine HCl relieves skeletal muscle spasm of local origin without interfering with muscle function. It is ineffective in muscle spasm due to central nervous system disease. Cyclobenzaprine reduced or abolished skeletal muscle hyperactivity in several animal models. Animal studies indicate that Cyclobenzaprine does not act at the neuromuscular junction or directly on skeletal muscle. Such studies show that Cyclobenzaprine acts primarily within the central nervous system at brain stem as opposed to spinal cord levels, although its action on the latter may contribute to its overall skeletal muscle relaxant activity. Evidence suggests that the net effect of Cyclobenzaprine is a reduction of tonic somatic motor activity, influencing both gamma (. Cyclobenzaprine exhibits linear pharmacokinetics over the dose range 2. It is highly bound to plasma proteins. Drug accumulates when dosed three times a day, reaching steady- state within 3- 4 days at plasma concentrations about four- fold higher than after a single dose. At steady state in healthy subjects receiving 1. Cytochromes P- 4. A4, 1. A2, and, to a lesser extent, 2. D6, mediate N- demethylation, one of the oxidative pathways for Cyclobenzaprine. Cyclobenzaprine is eliminated quite slowly, with an effective half- life of 1. L/min. The plasma concentration of Cyclobenzaprine is generally higher in the elderly and in patients with hepatic impairment. Elderly male subjects had the highest observed mean increase, approximately 2. L, range 1. 55. 6 to 2. L, range 4. 1. 1 to 1. L, range 9. 6. 1 to 1. L, range 3. 6. 1 to 1. In light of these findings, therapy with Cyclobenzaprine HCl in the elderly should be initiated with a 5 mg dose and titrated slowly upward. Hepatic Impairment. In a pharmacokinetic study of sixteen subjects with hepatic impairment (1. Child- Pugh score), both AUC and Cmax were approximately double the values seen in the healthy control group. Based on the findings, Cyclobenzaprine HCl should be used with caution in subjects with mild hepatic impairment starting with the 5 mg dose and titrating slowly upward. Due to the lack of data in subjects with more severe hepatic insufficiency, the use of Cyclobenzaprine HCl in subjects with moderate to severe impairment is not recommended. No significant effect on plasma levels or bioavailability of Cyclobenzaprine HCl or aspirin was noted when single or multiple doses of the two drugs were administered concomitantly. Concomitant administration of Cyclobenzaprine HCl and naproxen or diflunisal was well tolerated with no reported unexpected adverse effects. However combination therapy of Cyclobenzaprine HCl with naproxen was associated with more side effects than therapy with naproxen alone, primarily in the form of drowsiness. No well- controlled studies have been performed to indicate that Cyclobenzaprine HCl enhances the clinical effect of aspirin or other analgesics, or whether analgesics enhance the clinical effect of Cyclobenzaprine HCl in acute musculoskeletal conditions. Clinical Studies. Eight double- blind controlled clinical studies were performed in 6. Cyclobenzaprine HCl 1. Muscle spasm, local pain and tenderness, limitation of motion, and restriction in activities of daily living were evaluated. In three of these studies there was a significantly greater improvement with Cyclobenzaprine HCl than with diazepam, while in the other studies the improvement following both treatments was comparable. Although the frequency and severity of adverse reactions observed in patients treated with Cyclobenzaprine HCl were comparable to those observed in patients treated with diazepam, dry mouth was observed more frequently in patients treated with Cyclobenzaprine HCl and dizziness more frequently in those treated with diazepam. The incidence of drowsiness, the most frequent adverse reaction, was similar with both drugs. The efficacy of Cyclobenzaprine HCl 5 mg was demonstrated in two seven- day, double- blind, controlled clinical trials enrolling 1. One study compared Cyclobenzaprine HCl 5 and 1. Primary endpoints for both trials were determined by patient- generated data and included global impression of change, medication helpfulness, and relief from starting backache. Each endpoint consisted of a score on a 5- point rating scale (from 0 or worst outcome to 4 or best outcome). Secondary endpoints included a physician’s evaluation of the presence and extent of palpable muscle spasm. Comparisons of Cyclobenzaprine HCl 5 mg and placebo groups in both trials established the statistically significant superiority of the 5 mg dose for all three primary endpoints at day 8 and, in the study comparing 5 and 1. A similar effect was observed with Cyclobenzaprine HCl 1. Physician- assessed secondary endpoints also showed that Cyclobenzaprine HCl 5 mg was associated with a greater reduction in palpable muscle spasm than placebo. Analysis of the data from controlled studies shows that Cyclobenzaprine HCl produces clinical improvement whether or not sedation occurs. The overall effectiveness of Cyclobenzaprine HCl was similar to that observed in the double- blind controlled studies; the overall incidence of adverse effects was less (see ADVERSE REACTIONS). Indications and Usage for Cyclobenzaprine. Cyclobenzaprine HCl is indicated as an adjunct to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions. Improvement is manifested by relief of muscle spasm and its associated signs and symptoms, namely, pain, tenderness, limitation of motion, and restriction in activities of daily living. Cyclobenzaprine HCl should be used only for short periods (up to two or three weeks) because adequate evidence of effectiveness for more prolonged use is not available and because muscle spasm associated with acute, painful musculoskeletal conditions is generally of short duration and specific therapy for longer periods is seldom warranted. Cyclobenzaprine HCl has not been found effective in the treatment of spasticity associated with cerebral or spinal cord disease, or in children with cerebral palsy. Contraindications. Hypersensitivity to any component of this product. Concomitant use of monoamine oxidase (MAO) inhibitors or within 1. Hyperpyretic crisis seizures, and deaths have occurred in patients receiving Cyclobenzaprine (or structurally similar tricyclic antidepressants) concomitantly with MAO inhibitor drugs. Acute recovery phase of myocardial infarction, and patients with arrhythmias, heart block or conduction disturbances, or congestive heart failure. Hyperthyroidism. Warnings. Serotonin Syndrome. The development of a potentially life- threatening serotonin syndrome has been reported with Cyclobenzaprine Hydrochloride when used in combination with other drugs, such as selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), tramadol, bupropion, meperidine, verapamil, or MAO inhibitors. The concomitant use of Cyclobenzaprine Hydrochloride with MAO inhibitors is contraindicated (see CONTRAINDICATIONS). Serotonin syndrome symptoms may include mental status changes (e. Treatment with Cyclobenzaprine Hydrochloride and any concomitant serotonergic agents should be discontinued immediately if the above reactions occur and supportive symptomatic treatment should be initiated. If concomitant treatment with Cyclobenzaprine Hydrochloride and other serotonergic drugs is clinically warranted, careful observation is advised, particularly during treatment initiation or dose increases (see PRECAUTIONS, Drug Interactions). Cyclobenzaprine is closely related to the tricyclic antidepressants, e. In short term studies for indications other than muscle spasm associated with acute musculoskeletal conditions, and usually at doses somewhat greater than those recommended for skeletal muscle spasm, some of the more serious central nervous system reactions noted with the tricyclic antidepressants have occurred (see WARNINGS, below, and ADVERSE REACTIONS). Tricyclic antidepressants have been reported to produce arrhythmias, sinus tachycardia, prolongation of the conduction time leading to myocardial infarction and stroke. Cyclobenzaprine HCl may enhance the effects of alcohol, barbiturates, and other CNS depressants. Precautions. General. Because of its atropine- like action, Cyclobenzaprine HCl should be used with caution in patients with a history of urinary retention, angle- closure glaucoma, increased intraocular pressure, and in patients taking anticholinergic medication. Impaired Hepatic Function. The plasma concentration of Cyclobenzaprine is increased in patients with hepatic impairment (see CLINICAL PHARMACOLOGY, Pharmacokinetics, Hepatic Impairment). These patients are generally more susceptible to drugs with potentially sedating effects, including Cyclobenzaprine. Cyclobenzaprine HCl should be used with caution in subjects with mild hepatic impairment starting with a 5 mg dose and titrating slowly upward. Due to the lack of data in subjects with more severe hepatic insufficiency, the use of Cyclobenzaprine HCl in subjects with moderate to severe impairment is not recommended. Information for Patients.
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